Public Health Emergencies Require Urgent Advice From The WHO

The World Health Organization (WHO) has developed a new mechanism, described in this week’s PLoS Medicine, for issuing urgent guidelines to health
professionals in a public health emergency such as an infectious disease outbreak.

The first rapidly issued guideline was developed by the WHO in order to advise countries that were dealing with avian influenza A (H5N1) infection.

Typically, the most rigorous clinical practice guidelines take two years or more to develop. The laborious process involves convening experts who
search for and appraise all the relevant research literature, and who meet several times before making treatment recommendations. Such a time frame
is clearly not practical in an emergency situation.

Holger J. SchГјnemann and colleagues, authors of the rapidly issued guideline on H5N1 infection, say that it took just one month to convene an expert
team, and only five weeks for the team to summarize the evidence and prepare draft guidelines. The guidelines were then discussed at a two-day
meeting, after which a draft manuscript for publication was prepared within 10 days.

In a related editorial discussing how WHO is responding to global public health threats, the PLoS Medicine editors comment that while the time scale
for developing the H5N1 guideline was “miraculously quick in WHO terms”, an even quicker time frame is sometimes going to be needed.

Citation:
SchГјnemann HJ, Hill SR, Kakad M, Vist GE, Bellamy R, et al. (2007)
Transparent development of the WHO Rapid Advice Guidelines.
PLoS Med 4(5): e119.
Link

About PLoS Medicine

PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of
human health and disease, together with commentary and analysis of important global health issues. For more information, visit
plosmedicine

About the Public Library of Science

The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world’s scientific and medical
literature a freely available public resource. For more information, visit plos

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